Two Spx proteins modulate stress tolerance , survival , 4 and virulence in Streptococcus mutans 5 6 7
نویسندگان
چکیده
6 7 Jessica K. Kajfasz , Isamar Rivera-Ramos , Jacqueline Abranches , Alaina R. 8 Martinez , Pedro L. Rosalen , Adam M. Derr , Robert G. Quivey 1,2 and José A. 9 Lemos 1,2* 10 11 12 Center for Oral Biology 1 and Department of Microbiology and Immunology , University 13 of Rochester Medical Center, Rochester, New York 14642; Piracicaba Dental School, 14 Department of Physiological Sciences, University of Campinas, Piracicaba, SP, Brazil 3 15 16 Running title: Streptococcus Spx 17 18 19 20 * Corresponding author. Mailing address: Center for Oral Biology, Box 611, 601 21 Elmwood Ave., University of Rochester Medical Center, Rochester, NY 14642. Phone: 22 (585) 275-1850. Fax: (585) 276-0190. E-mail: [email protected]. 23 24 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00028-10 JB Accepts, published online ahead of print on 16 March 2010
منابع مشابه
Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.
Previous work suggested that the underlying mechanisms by which the Streptococcus mutans ClpXP protease affects virulence traits are associated with accumulation of two orthologues of the Spx regulator, named SpxA and SpxB. Here, a thorough characterization of strains lacking the spx genes (Delta spxA, Delta spxB, and Delta spxA Delta spxB) revealed that Spx, indeed, participates in the regulat...
متن کاملRole of Clp proteins in expression of virulence properties of Streptococcus mutans.
Mutational analysis revealed that members of the Clp system, specifically the ClpL chaperone and the ClpXP proteolytic complex, modulate the expression of important virulence attributes of Streptococcus mutans. Compared to its parent, the DeltaclpL strain displayed an enhanced capacity to form biofilms in the presence of sucrose, had reduced viability, and was more sensitive to acid killing. Th...
متن کاملSpxA1 Involved in Hydrogen Peroxide Production, Stress Tolerance and Endocarditis Virulence in Streptococcus sanguinis
Streptococcus sanguinis is one of the most common agents of infective endocarditis. Spx proteins are a group of global regulators that negatively or positively control global transcription initiation. In this study, we characterized the spxA1 gene in S. sanguinis SK36. The spxA1 null mutant displayed opaque colony morphology, reduced hydrogen peroxide (H(2)O(2)) production, and reduced antagoni...
متن کاملTwo Spx Regulators Modulate Stress Tolerance and Virulence in Streptococcus suis Serotype 2
Streptococcus suis serotype 2 is an important zoonotic pathogen causing severe infections in pigs and humans. The pathogenesis of S. suis 2 infections, however, is still poorly understood. Spx proteins are a group of global regulators involved in stress tolerance and virulence. In this study, we characterized two orthologs of the Spx regulator, SpxA1 and SpxA2 in S. suis 2. Two mutant strains (...
متن کاملStreptococcus mutans copes with heat stress by multiple transcriptional regulons modulating virulence and energy metabolism
Dental caries is closely associated with the virulence of Streptococcus mutans. The virulence expression of S. mutans is linked to its stress adaptation to the changes in the oral environment. In this work we used whole-genome microarrays to profile the dynamic transcriptomic responses of S. mutans during physiological heat stress. In addition, we evaluated the phenotypic changes, including, eD...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010